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>   首页   >   产品   >   一抗   >   心血管   >   GNE Antibody   

GNE Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GNE Antibody AP50603
    Western blot analysis of lysate from human liver tissue lysate,using GNE Antibody(AP50603). AP50603 was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 2 - GNE Antibody AP50603
    Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using GNE antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession Q9Y223
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 79,83,79,71,67 KDa
Additional info
Gene ID 10020
Other Names Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE
Dilution WB~~ 1:500
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name GNE
Synonyms GLCNE
Function Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Cellular Location Cytoplasm.
Tissue Location Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon.
Research Areas

BACKGROUND

Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.

REFERENCES

Lucka L.,et al.FEBS Lett. 454:341-344(1999).
Seppala R.,et al.Am. J. Hum. Genet. 64:1563-1569(1999).
Wang S.S.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Huizing M.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Pramono Z.A.D.,et al.Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.

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