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>   首页   >   产品   >   一抗   >   癌症   >   WASF2 Antibody   

WASF2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - WASF2 Antibody AP50212
    Western blot analysis of lysate from Ramos cell line,using WASF2 Antibody(C19560). C19560 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 2 - WASF2 Antibody AP50212
    Immunohistochemistry analysis of paraffin-embedded human pancreas tissue, using WASF2antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession Q9Y6W5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 54,32,实际80 KDa
Additional info
Gene ID 10163
Other Names Wiskott-Aldrich syndrome protein family member 2, WASP family protein member 2, Protein WAVE-2, Verprolin homology domain-containing protein 2, WASF2, WAVE2
Dilution WB~~ 1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name WASF2
Synonyms WAVE2
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Cellular Location Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=At the interface between the lamellipodial actin meshwork and the membrane
Tissue Location Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.
Research Areas

BACKGROUND

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

REFERENCES

Suetsugu S.,et al.Biochem. Biophys. Res. Commun. 260:296-302(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Miki H.,et al.Nature 408:732-735(2000).
Gautreau A.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:4379-4383(2004).

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