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>   首页   >   产品   >   一抗   >   信号转导   >   Catenin-γ Antibody   

Catenin-γ Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Catenin-γ Antibody AP50192
    Western blot analysis of lysate from MCF-7 cell line,using Catenin-γ Antibody(C0138). C0138 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 2 - Catenin-γ Antibody AP50192
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Catenin-γ antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P14923
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 82 KDa
Additional info
Gene ID 3728
Other Names Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
Dilution WB~~ 1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name JUP
Synonyms CTNNG, DP3
Function Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Cellular Location Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form
Research Areas

BACKGROUND

Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).

REFERENCES

Franke W.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:4027-4031(1989).
Zimbelmann R.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
Whittock N.V.,et al.Exp. Dermatol. 9:323-326(2000).
Liang X.-J.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).

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