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>   首页   >   产品   >   一抗   >   信号转导   >   ARHGEF1 Antibody   

ARHGEF1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ARHGEF1 Antibody AP50069
    Western blot analysis of lysate from Hela cell line,using ARHGEF1 Antibody(C18385). C18385 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q92888
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 102,99,104 KDa
Additional info
Gene ID 9138
Other Names Rho guanine nucleotide exchange factor 1, 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub15, ARHGEF1
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name ARHGEF1
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.
Cellular Location Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation
Tissue Location Ubiquitously expressed.
Research Areas

BACKGROUND

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.

REFERENCES

Hart M.J.,et al.J. Biol. Chem. 271:25452-25458(1996).
Aasheim H.-C.,et al.Oncogene 14:1747-1752(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Kozasa T.,et al.Science 280:2109-2111(1998).
Hart M.J.,et al.Science 280:2112-2114(1998).

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