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>   首页   >   产品   >   一抗   >   癌症   >   Cytochrome P450 2A6 Antibody   

Cytochrome P450 2A6 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Cytochrome P450 2A6 Antibody AP50056
    Western blot analysis of lysates from H.liver cell line ,using Cytochrome P450 2A6 Antibody(C12258). C12258 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P11509
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 57 KDa
Additional info
Gene ID 1548
Other Names Cytochrome P450 2A6, 11413-, 4-cineole 2-exo-monooxygenase, CYPIIA6, Coumarin 7-hydroxylase, Cytochrome P450 IIA3, Cytochrome P450(I), CYP2A6, CYP2A3
Dilution WB~~ 1:500-1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name CYP2A6
Synonyms CYP2A3
Function Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Tissue Location Liver.
Research Areas

BACKGROUND

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity.

REFERENCES

Miles J.S.,et al.Nucleic Acids Res. 17:2907-2917(1989).
Yamano S.,et al.Nucleic Acids Res. 17:4888-4888(1989).
Yamano S.,et al.Biochemistry 29:1322-1329(1990).
Zhuge J.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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