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>   首页   >   产品   >   一抗   >   精选抗体   >   G蛋白偶联受体抗体(GPCR)   >   mGluR6 Antibody   

mGluR6 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - mGluR6 Antibody AP50050
    Western blot analysis of lysates from K562 cell line ,using mGluR6 Antibody(C0210). C0210 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.
  • 2 - mGluR6 Antibody AP50050
    Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR6 antibody .
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession O15303
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 95 KDa
Additional info
Gene ID 2916
Other Names Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6
Dilution WB~~ 1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name GRM6
Synonyms GPRC1F, MGLUR6
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Cellular Location Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane
Tissue Location Detected in melanocytes.
Research Areas

BACKGROUND

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

REFERENCES

Hashimoto T.,et al.Eur. J. Neurosci. 9:1226-1235(1997).
Schmutz J.,et al.Nature 431:268-274(2004).
Devi S.,et al.Pigment Cell Melanoma Res. 26:348-356(2013).
Dryja T.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:4884-4889(2005).
Sjoeblom T.,et al.Science 314:268-274(2006).

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