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CDC2L1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CDC2L1 Antibody AP50040
    Western blot analysis of lysates from Hela cell line ,using CDC2L1 Antibody(C10442). C10442 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P21127
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 93 KDa
Additional info
Gene ID 984
Other Names Cyclin-dependent kinase 11B, Cell division cycle 2-like protein kinase 1, CLK-1, Cell division protein kinase 11B, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L1, p58 CLK-1, CDK11B, CDC2L1, CDK11, PITSLREA, PK58
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name CDK11B
Synonyms CDC2L1, CDK11, PITSLREA, PK58
Function Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
Research Areas

BACKGROUND

Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

REFERENCES

Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7467-7471(1990).
Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:2612-2612(1991).
Eipers P.G.,et al.Genomics 13:613-621(1992).
Xiang J.,et al.J. Biol. Chem. 269:15786-15794(1994).
Gururajan R.,et al.Genome Res. 8:929-939(1998).

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