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>   首页   >   产品   >   一抗   >   精选抗体   >   G蛋白偶联受体抗体(GPCR)   >   Adrenergic Receptor alpha-2B Antibody   

Adrenergic Receptor alpha-2B Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Adrenergic Receptor alpha-2B Antibody AP50039
    Western blot analysis of lysates from MCF-7 cell line ,using Adrenergic Receptor alpha-2B Antibody(C10415). C10415 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.
  • 3 - Adrenergic Receptor alpha-2B Antibody AP50039
    Immunofluorescence analysis of HepG2 cells, using Adrenergic Receptor alpha-2B antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF
Primary Accession P18089
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 50 KDa
Additional info
Gene ID 151
Other Names Alpha-2B adrenergic receptor, Alpha-2 adrenergic receptor subtype C2, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor, Alpha-2BAR, ADRA2B, ADRA2L1, ADRA2RL1
Dilution WB~~ 1:1000
IF~~1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name ADRA2B
Synonyms ADRA2L1, ADRA2RL1
Function Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Cellular Location Cell membrane; Multi-pass membrane protein Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane
Research Areas

BACKGROUND

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

REFERENCES

Lomasney J.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5094-5098(1990).
Weinshank R.L.,et al.Mol. Pharmacol. 38:681-688(1990).
Small K.M.,et al.J. Biol. Chem. 276:4917-4922(2001).
Cayla C.,et al.Biochem. Pharmacol. 67:469-478(2004).
Kopatz S.A.,et al.Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.

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