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>   首页   >   产品   >   一抗   >   癌症   >   PLCG1 (Ab-771) Antibody   

PLCG1 (Ab-771) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PLCG1 (Ab-771) Antibody AP50025
    Western blot analysis of lysates from Hela cell line ,using PLCG1 (Ab-771) Antibody(B0079). B0079 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.
  • 1 - PLCG1 (Ab-771) Antibody AP50025
    Western blot analysis of extracts from COS7 cells (Lane 1), and JK cells (Lane 2), using PLCG1 (Ab-771) Antibody. The lane on the left is treated with synthesized peptide.
  • 2 - PLCG1 (Ab-771) Antibody AP50025
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLCG1 (Ab-771) antibody .
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P19174
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 149 KDa
Additional info
Gene ID 5335
Other Names 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1, PLC1
Dilution WB~~ 1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name PLCG1
Synonyms PLC1
Function Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Cellular Location Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment
Research Areas

BACKGROUND

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

REFERENCES

Burgess W.H.,et al.Mol. Cell. Biol. 10:4770-4777(1990).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mohammadi M.,et al.Mol. Cell. Biol. 11:5068-5078(1991).
Park D.J.,et al.J. Biol. Chem. 267:1496-1501(1992).

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