AML1 Antibody (Ab-435)
Purified Rabbit Polyclonal Antibody (Pab)
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| WB |
---|---|
Primary Accession | Q01196 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | polyclonal |
Calculated MW | 49, KDa |
Gene ID | 861 |
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Other Names | Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, RUNX1, AML1, CBFA2 |
Dilution | WB~~ 1:1000 |
Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage Conditions | -20℃ |
Name | RUNX1 |
---|---|
Synonyms | AML1, CBFA2 |
Function | CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood |
BACKGROUND
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation.
REFERENCES
Ahn M.-Y.,et al.Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
Miyoshi H.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991).
Sacchi N.,et al.Genes Chromosomes Cancer 11:226-236(1994).
Nucifora G.,et al.Blood 81:2728-2734(1993).
Levanon D.,et al.Genomics 23:425-432(1994).

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