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>   首页   >   产品   >   一抗   >   癌症   >   Caveolin-1 Antibody   

Caveolin-1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Caveolin-1 Antibody AP50008
    Western blot analysis of lysate from Hela cell line,using Caveolin-1 Antibody(C0139). C0139 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 1 - Caveolin-1 Antibody AP50008
    Western blot analysis of extracts from HUVEC cells (Lane 1), colo cells (Lane 2) and JK cells (Lane 3), using Caveolin-1 Antibody. The lane on the left is treated with synthesized peptide.
  • 3 - Caveolin-1 Antibody AP50008
    Immunofluorescence analysis of HuvEc cells, using Caveolin-1 antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF
Primary Accession Q03135
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 20,17 KDa
Additional info
Gene ID 857
Other Names Caveolin-1, CAV1, CAV
Dilution WB~~ 1:1000
IF~~1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name CAV1
Synonyms CAV
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Cellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Membrane raft Note=Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae
Tissue Location Expressed in muscle and lung, less so in liver, brain and kidney
Research Areas

BACKGROUND

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

REFERENCES

Glenney J.R. Jr.,et al.FEBS Lett. 314:45-48(1992).
Hurlstone A.F.,et al.Oncogene 18:1881-1890(1999).
Engelman J.A.,et al.FEBS Lett. 448:221-230(1999).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Vainonen J.P.,et al.Biochem. Biophys. Res. Commun. 320:480-486(2004).

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