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>   首页   >   产品   >   一抗   >   癌症   >   p130 Cas Antibody (Ab-410)    

p130 Cas Antibody (Ab-410)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - p130 Cas Antibody (Ab-410)  AP50000
    Western blot analysis of lysates from Hela,HepG2 cell line (from left to right),using p130 Cas Antibody (Ab-410) (B0077). B0077 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • 2 - p130 Cas Antibody (Ab-410)  AP50000
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p130 Cas (Ab-410) antibody .
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P56945
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 93 KDa
Additional info
Gene ID 9564
Other Names Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS
Dilution WB~~ 1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name BCAR1
Synonyms CAS, CASS1, CRKAS
Function Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
Cellular Location Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.
Tissue Location Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line
Research Areas

BACKGROUND

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

REFERENCES

Brinkman A.,et al.J. Natl. Cancer Inst. 92:112-120(2000).
Otto E.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Imoto Y.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Lin L.,et al.Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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