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CRIP1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CRIP1 Antibody (C-term) AP4707b
    All lanes : Anti-CRIP1 Antibody (C-term) at 1:8000 dilution Lane 1: T47D whole cell lysate Lane 2: THP-1 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 9 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - CRIP1 Antibody (C-term) AP4707b
    CRIP1 Antibody (C-term) (Cat. #AP4707b) IHC analysis in formalin fixed and paraffin embedded bladder carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRIP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - CRIP1 Antibody (C-term) AP4707b
    CRIP1 Antibody (C-term) (Cat. #AP4707b) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession P50238
Other Accession P63255, P63254, Q56K04
Reactivity Human
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Other Names Cysteine-rich protein 1, CRP-1, Cysteine-rich heart protein, CRHP, hCRHP, Cysteine-rich intestinal protein, CRIP, CRIP1, CRIP, CRP1
Target/Specificity This CRIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-77 amino acids from the C-terminal region of human CRIP1.
Dilution WB~~1:8000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRIP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRIP1
Synonyms CRIP, CRP1
Function Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. EMBL; U09770; AAA64537.1; -; mRNA. EMBL; U58630; AAB61158.1; -; mRNA. EMBL; BT007181; AAP35845.1; -; mRNA. EMBL; AL928654; -; NOT_ANNOTATED_CDS; Genomic_DNA. EMBL; BC002738; AAH02738.1; -; mRNA. CCDS; CCDS10004.1; -. PIR; G02666; G02666. PIR; JC2431; JC2431. RefSeq; NP_001302.1; NM_001311.4. UniGene; Hs.70327; -. ProteinModelPortal; P50238; -. SMR; P50238; -. BioGrid; 107786; 41. IntAct; P50238; 3. STRING; 9606.ENSP00000455329; -. iPTMnet; P50238; -. PhosphoSitePlus; P50238; -. BioMuta; CRIP1; -. DMDM; 20981688; -. EPD; P50238; -. jPOST; P50238; -. MaxQB; P50238; -. PaxDb; P50238; -. PeptideAtlas; P50238; -. PRIDE; P50238; -. ProteomicsDB; 56212; -. TopDownProteomics; P50238; -. DNASU; 1396; -. Ensembl; ENST00000330233; ENSP00000332449; ENSG00000213145. Ensembl; ENST00000392531; ENSP00000376315; ENSG00000213145. Ensembl; ENST00000409393; ENSP00000386340; ENSG00000213145. GeneID; 1396; -. KEGG; hsa:1396; -. UCSC; uc001yri.5; human. CTD; 1396; -. DisGeNET; 1396; -. EuPathDB; HostDB:ENSG00000213145.9; -. EuPathDB; HostDB:ENSG00000257341.5; -. GeneCards; CRIP1; -. HGNC; HGNC:2360; CRIP1. HPA; HPA042462; -. MIM; 123875; gene. neXtProt; NX_P50238; -. OpenTargets; ENSG00000213145; -. PharmGKB; PA26878; -. eggNOG; KOG1700; Eukaryota. eggNOG; COG5069; LUCA. GeneTree; ENSGT00940000162342; -. HOGENOM; HOG000264233; -. HOVERGEN; HBG051118; -. InParanoid; P50238; -. OMA; CNKTLSA; -. OrthoDB; 1214165at2759; -. PhylomeDB; P50238; -. GeneWiki; CRIP1; -. GenomeRNAi; 1396; -. PRO; PR:P50238; -. Proteomes; UP000005640; Chromosome 14. Bgee; ENSG00000213145; Expressed in 92 organ(s), highest expression level in right coronary artery. Genevisible; P50238; HS. GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. GO; GO:0003680; F:AT DNA binding; IDA:UniProtKB. GO; GO:0008301; F:DNA binding, bending; IDA:UniProtKB. GO; GO:0042277; F:peptide binding; IDA:UniProtKB. GO; GO:0008270; F:zinc ion binding; IDA:UniProtKB. GO; GO:0008283; P:cell population proliferation; TAS:UniProtKB. GO; GO:0071236; P:cellular response to antibiotic; IDA:UniProtKB. GO; GO:0071493; P:cellular response to UV-B; IDA:UniProtKB. GO; GO:0007507; P:heart development; TAS:UniProtKB. GO; GO:0006955; P:immune response; IEP:UniProtKB. GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:UniProtKB. GO; GO:0060741; P:prostate gland stromal morphogenesis; IEP:UniProtKB. GO; GO:0010468; P:regulation of gene expression; IEP:UniProtKB. GO; GO:0010033; P:response to organic substance; IEP:UniProtKB. GO; GO:0010043; P:response to zinc ion; IDA:UniProtKB. InterPro; IPR001781; Znf_LIM. Pfam; PF00412; LIM; 1. SMART; SM00132; LIM; 1. PROSITE; PS00478; LIM_DOMAIN_1; 1. PROSITE; PS50023; LIM_DOMAIN_2; 1. 1: Evidence at protein level; Acetylation; Complete proteome; LIM domain; Metal-binding; Methylation; Reference proteome; Zinc. CHAIN 1 77 Cysteine-rich protein 1. /FTId=PRO_0000075707. DOMAIN 2 63 LIM zinc-binding. SEQUENCE 77 AA; 8533 MW; B342436418DBC021 CRC64; MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP YCNHPCYAAM FGPKGFGRGG AESHTFK
Research Areas
Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts.
Author : Straubinger J1,Boldt K2,Kuret A1,Deng L1,Krattenmacher D3,Bork N1,Desch M1,Feil R4,Feil S4,Nemer M5,Ueffing M2,Ruth P1,Just S3,Lukowski R6.
FASEB J. 2017 Jan 30. pii: fj.201601186. doi: 10.1096/fj.201601186. [Epub ahead of print]
28138039

BACKGROUND

Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport.

REFERENCES

Garcia-Barcelo, M., et al. Genomics 47(3):419-422(1998)
Khoo, C., et al. Protein Expr. Purif. 9(3):379-387(1997)

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