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SC24A Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SC24A Antibody (Center) AP4701c
    Western blot analysis of SC24A Antibody (Center) (Cat. #AP4701c) in T47D cell line lysates (35ug/lane). SC24A (arrow) was detected using the purified Pab.
  • 14 - SC24A Antibody (Center) AP4701c
    SC24A Antibody (Center) (Cat. #AP4701c) IHC analysis in formalin fixed and paraffin embedded hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SC24A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession O95486
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 119749 Da
Additional info
Gene ID 10802
Other Names Protein transport protein Sec24A, SEC24-related protein A, SEC24A
Target/Specificity This SC24A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-663 amino acids from the Central region of human SC24A.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSC24A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEC24A (HGNC:10703)
Function Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).
Cellular Location Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol
Research Areas

BACKGROUND

SC24A is a component of coat protein II (COPII; see MIM 601924)-coated vesicles that mediate protein transport from the endoplasmic reticulum. SEC24A is 1 of several mammalian proteins that show structural and functional homology to yeast Sec24.

REFERENCES

Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Mancias, J.D., et al. Mol. Cell 26(3):403-414(2007)
Wendeler, M.W., et al. EMBO Rep. 8(3):258-264(2007)

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