|Application ||WB, E|
|Calculated MW||36085 Da|
|Other Names||Lymphokine-activated killer T-cell-originated protein kinase, 22.214.171.124, Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase, PBK, TOPK|
|Target/Specificity||This Phospho-PBK/TOPK (Thr9) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-35 amino acids from the human Phospho-PBK/TOPK.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-PBK/TOPK (Thr9) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.|
|Tissue Location||Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.|
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Abe Y.,et al.J. Biol. Chem. 275:21525-21531(2000).
Gaudet S.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5167-5172(2000).
Zhao S.,et al.Int. J. Biochem. Cell Biol. 33:631-636(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).