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PRDX6 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PRDX6 Antibody (Center) AP2927c
    PRDX6 Antibody (Center) (Cat.#AP2927c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PRDX6 antibody detected the PRDX6 protein (arrow).
  • 14 - PRDX6 Antibody (Center) AP2927c
    PRDX6 Antibody (Center) (Cat. #AP2927c) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PRDX6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - PRDX6 Antibody (Center) AP2927c
    PRDX6 Antibody (Center) (Cat. #AP2927c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession P30041
Other Accession O35244, Q2PFL9, O77834, NP_004896
Reactivity Human
Predicted Bovine, Monkey, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 25035 Da
Additional info
Gene ID 9588
Other Names Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, 311-, Antioxidant protein 2, Liver 2D page spot 40, Non-selenium glutathione peroxidase, NSGPx, Red blood cells page spot 12, PRDX6, AOP2, KIAA0106
Target/Specificity This PRDX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human PRDX6.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRDX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDX6
Synonyms AOP2, KIAA0106
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
Cellular Location Cytoplasm. Lysosome {ECO:0000250|UniProtKB:O35244}. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250|UniProtKB:O35244}
Research Areas

BACKGROUND

PRDX6 is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

REFERENCES

Davila, S., et al. Genes Immun. (2010) In press :
Kubo, E., et al. Am. J. Physiol., Cell Physiol. 298 (2), C342-C354 (2010) :
Sorokina, E.M., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 297 (5), L871-L880 (2009)

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