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>   首页   >   产品   >   一抗   >   心血管   >   CD201 Antibody (Center)   

CD201 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CD201 Antibody (Center) AP2887c
    Western blot analysis of CD201 antibody (Center) (Cat. #AP2887c) in T47D cell line lysates (35ug/lane). CD201 (arrow) was detected using the purified Pab.
  • 14 - CD201 Antibody (Center) AP2887c
    Formalin-fixed and paraffin-embedded human lung carcinoma with CD201 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 4 - CD201 Antibody (Center) AP2887c
    Flow cytometric analysis of NCI-H292 cells using CD201 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession Q9UNN8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 26671 Da
Additional info
Gene ID 10544
Other Names Endothelial protein C receptor, Activated protein C receptor, APC receptor, Endothelial cell protein C receptor, CD201, PROCR, EPCR
Target/Specificity This CD201 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-132 amino acids from the Central region of human CD201.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD201 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PROCR
Synonyms EPCR
Function Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney
Research Areas

BACKGROUND

PROCR (CD201) is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in its gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

REFERENCES

Menschikowski,M., Exp. Cell Res. 315 (15), 2673-2682 (2009)
Nayak,R.C., Blood 114 (9), 1974-1986 (2009)

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