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S adenosylhomocysteine hydrolase (ACHY) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - S adenosylhomocysteine hydrolase (ACHY) Antibody (C-term) AP2733b
    Western blot analysis of anti-AHCY Antibody (C-term)(Cat.#AP2733b) in HepG2 cell line lysates (35ug/lane). AHCY(arrow) was detected using the purified Pab.
  • 14 - S adenosylhomocysteine hydrolase (ACHY) Antibody (C-term) AP2733b
    Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AHCY antibody (C-term) (Cat.#AP2733b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P23526
Other Accession Q4R596
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47716 Da
Additional info
Gene ID 191
Other Names Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH
Target/Specificity This S adenosylhomocysteine hydrolase (ACHY) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-432 amino acids from the C-terminal region of human S adenosylhomocysteine hydrolase (ACHY).
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsS adenosylhomocysteine hydrolase (ACHY) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHCY
Synonyms SAHH
Function Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas

BACKGROUND

S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family.

REFERENCES

Yideng,J.,DNA Cell Biol. 26 (8), 603-611 (2007)
Arredondo-Vega,F.X.,Ann. Hum. Genet. 53 (PT 2), 157-167 (1989)
Li,Q.S.,Biochemistry 47 (17), 4983-4991 (2008)

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