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HERV (ERVWE1) Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - HERV (ERVWE1) Antibody (Center) AP2716c
    Western blot analysis of lysate from human brain tissue lysate, using Syncytin(ERVWE1) Antibody(Cat. #AP2716c). AP2716c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
  • 14 - HERV (ERVWE1) Antibody (Center) AP2716c
    Formalin-fixed and paraffin-embedded H.placenta tissue reacted with HERV (ERVWE1) Antibody (Center) (Cat#AP2716c).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9UQF0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59866 Da
Additional info
Gene ID 30816
Other Names Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
Target/Specificity This HERV (ERVWE1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the Central region of human HERV (ERVWE1).
Dilution WB~~1:1000
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHERV (ERVWE1) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERVW-1
Synonyms ERVWE1
Function This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).
Cellular Location Transmembrane protein: Cell membrane; Single-pass type I membrane protein Syncytin-1: Virion.
Tissue Location Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia
Research Areas

BACKGROUND

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. The protein, also known as syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. This protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

REFERENCES

Oluwole,S.O., Amyotroph Lateral Scler 8 (2), 67-72 (2007)
Gong,R., Cell. Physiol. Biochem. 20 (5), 517-526 (2007)
Antony,J.M., AIDS Res. Hum. Retroviruses 22 (12), 1253-1259 (2006)

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