|Application ||WB, E|
|Calculated MW||91296 Da|
|Other Names||Mitogen-activated protein kinase kinase kinase kinase 1, 18.104.22.168, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1|
|Target/Specificity||This MAP4K1-T165 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 140-180 from the human region of human MAP4K1-T165.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAP4K1-T165 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.|
|Tissue Location||Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine|
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
Hu M.C.-T.,et al.Genes Dev. 10:2251-2264(1996).
Grimwood J.,et al.Nature 428:529-535(2004).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).