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>   首页   >   产品   >   一抗   >   癌症   >   HSPA1A/HSPA1B Antibody (Y41)   

HSPA1A/HSPA1B Antibody (Y41)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - HSPA1A/HSPA1B Antibody (Y41) AP22369a
    All lanes : Anti-HSPA1A/HSPA1B Antibody (Y41) at 1:1000 dilution Lane 1: Jurkat whole cell lysate Lane 2: Hela whole cell lysate Lane 3: 293 whole cell lysate Lane 4: MCF-7 whole cell lysate Lane 5: C2C12 whole cell lysate Lane 6: NIH/3T3 whole cell lysate Lane 7: C6 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 70 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P08107
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 70052 Da
Additional info
Gene ID 3303;3304
Other Names Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2, HSPA1A, HSPA1, HSX70
Target/Specificity This HSPA1A/HSPA1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human HSPA1A/HSPA1B.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSPA1A/HSPA1B Antibody (Y41) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPA1A
Synonyms HSPA1, HSX70
Function In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
Cellular Location Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Tissue Location HSPA1B is testis-specific.
Research Areas

BACKGROUND

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

REFERENCES

Milner C.M.,et al.Immunogenetics 32:242-251(1990).
Hunt C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6455-6459(1985).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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