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NCR3 Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NCR3 Antibody (N-Term) AP22356a
    All lanes : Anti-NCR3 Antibody (N-Term) at 1:1000 dilution Lane 1: Jurkat whole cell lysate Lane 2: Daudi whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 22 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O14931
Other Accession P61484
Reactivity Human
Predicted Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 21593 Da
Additional info
Gene ID 259197
Other Names Natural cytotoxicity triggering receptor 3, Activating natural killer receptor p30, Natural killer cell p30-related protein, NK-p30, NKp30, CD337, NCR3, 1C7, LY117
Target/Specificity This NCR3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 31-65 amino acids from the human region of human NCR3.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNCR3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCR3
Synonyms 1C7, LY117
Function Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Selectively expressed by all resting and activated NK cells and weakly expressed in spleen {ECO:0000269|PubMed:10562324, ECO:0000269|Ref.2}
Research Areas

BACKGROUND

Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

REFERENCES

Pende D.,et al.J. Exp. Med. 190:1505-1516(1999).
Sato M.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Neville M.J.,et al.J. Immunol. 162:4745-4754(1999).
Nalabolu S.R.,et al.Genomics 31:215-222(1996).
Xie T.,et al.Genome Res. 13:2621-2636(2003).

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