|Application ||WB, IHC-P-Leica, E|
|Calculated MW||101209 Da|
|Other Names||Urea transporter 2, Solute carrier family 14 member 2, Urea transporter, kidney, SLC14A2, HUT2, UT2|
|Target/Specificity||This SLC14A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 42-76 amino acids from the human region of human SLC14A2.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC14A2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.|
Provided below are standard protocols that you may find useful for product applications.
Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
Olives B.,et al.FEBS Lett. 386:156-160(1996).
Bagnasco S.M.,et al.Am. J. Physiol. 281:F400-F406(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mistry A.C.,et al.J. Biol. Chem. 282:30097-30106(2007).