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>   首页   >   产品   >   一抗   >   细胞生物学   >   DLL4 Antibody   

DLL4 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DLL4 Antibody AP22346a
    All lanes : Anti-DLL4 Antibody at 1:2000 dilution Lane 1: Mouse kidney lysate Lane 2: Mouse lung lysate Lane 3: Rat lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 75 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9NR61
Reactivity Mouse, Rat
Predicted Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 74605 Da
Additional info
Gene ID 54567
Other Names Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
Target/Specificity This DLL4 antibody is generated from a rabbit immunized with a recombinant protein from the human region of human DLL4.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDLL4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLL4
Function Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in vascular endothelium.
Research Areas

BACKGROUND

Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

REFERENCES

Shutter J.R.,et al.Genes Dev. 14:1313-1318(2000).
Sakano S.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Yoneya T.,et al.J. Biochem. 129:27-34(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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