BRAF Antibody(C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| IHC-P, WB, E |
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Primary Accession | P15056 |
Other Accession | Q04982, P34908, P28028, P00531, A7E3S4, P05625, P04049, Q99N57, Q5R5M7, P11345, P00532, P27966, P10533 |
Reactivity | Human |
Predicted | Bovine, Chicken, Human, Mouse, Rat |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit Ig |
Calculated MW | 84437 Da |
Gene ID | 673 |
---|---|
Other Names | Serine/threonine-protein kinase B-raf, 2.7.11.1, Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, BRAF, BRAF1, RAFB1 |
Target/Specificity | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 576-606 amino acids from human. |
Dilution | IHC-P~~1:25 WB~~1:2000 |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BRAF Antibody(C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BRAF |
---|---|
Synonyms | BRAF1, RAFB1 |
Function | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. |
Cellular Location | Nucleus. Cytoplasm. Cell membrane. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. |
Tissue Location | Brain and testis. |
Research Areas
BACKGROUND
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
REFERENCES
Stephens R.M.,et al.Mol. Cell. Biol. 12:3733-3742(1992).
Albert S.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Scherer S.W.,et al.Science 300:767-772(2003).
Hillier L.W.,et al.Nature 424:157-164(2003).
Eychene A.,et al.Oncogene 7:1657-1660(1992).

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