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MST1R Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MST1R Antibody (Center) AP22294c
    All lanes : Anti-MST1R Antibody (Center) at 1:1000-1:2000 dilution Lane 1: HACAT whole cell lysate Lane 2: HCT116 whole cell lysate Lane 3: SK-BR-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 152 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q04912
Reactivity Human
Predicted Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 152271 Da
Additional info
Gene ID 4486
Other Names Macrophage-stimulating protein receptor, MSP receptor, 2.7.10.1, CDw136, Protein-tyrosine kinase 8, p185-Ron, CD136, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, MST1R, PTK8, RON
Target/Specificity This MST1R antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 600-633 amino acids from the Central region of human MST1R.
Dilution WB~~1:1000-1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMST1R Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MST1R
Synonyms PTK8, RON
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in colon, skin, lung and bone marrow.
Research Areas

BACKGROUND

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

REFERENCES

Ronsin C.,et al.Oncogene 8:1195-1202(1993).
Collesi C.,et al.Mol. Cell. Biol. 16:5518-5526(1996).
Jin P.,et al.Arthritis Res. Ther. 10:R73-R73(2008).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ponzetto C.,et al.Mol. Cell. Biol. 13:4600-4608(1993).

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