|Application ||FC, WB, E|
|Other Accession||Q3ZC25, Q80X71, Q6AYA5|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||31127 Da|
|Other Names||Transmembrane protein 106B, TMEM106B|
|Target/Specificity||This TMEM106B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 218-252 amino acids from human TMEM106B.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMEM106B Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.|
|Cellular Location||Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in frontal cortex.|
Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).