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CD24 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CD24 Antibody (Center) AP22227c
    All lanes : Anti-CD24 Antibody (Center) at 1:1000-1:2000 dilution Lane 1: MOLT-4 whole cell lysate Lane 2: Raji whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 8 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P25063
Other Accession Q6SW14
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 8097 Da
Additional info
Gene ID 100133941
Other Names Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A
Target/Specificity This CD24 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 17-38 amino acids from the Central region of human CD24.
Dilution WB~~1:1000-1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD24 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD24
Synonyms CD24A
Function Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Location B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
Research Areas
CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways.
Author : Ni SJ1,2,3,Zhao LQ1,2,Wang XF1,2,Wu ZH1,2,Hua RX1,2,Wan CH4,Zhang JY1,2,Zhang XW1,2,Huang MZ1,2,Gan L1,2,Sun HL5,Dimri GP6,Guo WJ7,8.
J Hematol Oncol. 2018 Feb 8;11(1):17. doi: 10.1186/s13045-018-0562-z.
29422082

BACKGROUND

Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

REFERENCES

Kay R.,et al.J. Immunol. 147:1412-1416(1991).
Jackson D.,et al.Cancer Res. 52:5264-5270(1992).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Hough M.R.,et al.Genomics 22:154-161(1994).
Zarn J.A.,et al.Biochem. Biophys. Res. Commun. 225:384-391(1996).

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