- 文献引用 : 1
|Application ||WB, E|
|Calculated MW||8083 Da|
|Other Names||Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A|
|Target/Specificity||This CD24 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 17-38 amino acids from the Central region of human CD24.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD24 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.|
Author : Ni SJ1,2,3,Zhao LQ1,2,Wang XF1,2,Wu ZH1,2,Hua RX1,2,Wan CH4,Zhang JY1,2,Zhang XW1,2,Huang MZ1,2,Gan L1,2,Sun HL5,Dimri GP6,Guo WJ7,8.
J Hematol Oncol. 2018 Feb 8;11(1):17. doi: 10.1186/s13045-018-0562-z.
Provided below are standard protocols that you may find useful for product applications.
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
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