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PLAA Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PLAA Antibody (Center) AP22224c
    Anti-PLAA Antibody (Center) at 1:2000 dilution + U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 87 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9Y263
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 87157 Da
Additional info
Gene ID 9373
Other Names Phospholipase A-2-activating protein, PLA2P, PLAP, PLAA, PLAP
Target/Specificity This PLAA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 294-328 amino acids from the Central region of human PLAA.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLAA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLAA
Synonyms PLAP
Function Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).
Cellular Location Nucleus. Cytoplasm. Cell junction, synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains
Research Areas

BACKGROUND

Involved in the maintenance of ubiquitin levels.

REFERENCES

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Humphray S.J.,et al.Nature 429:369-374(2004).
Beatty B.,et al.Genomics 62:529-532(1999).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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