|Application ||WB, E|
|Calculated MW||70911 Da|
|Other Names||Mannosyl-oligosaccharide 1, 2-alpha-mannosidase IC, 22.214.171.124, HMIC, Mannosidase alpha class 1C member 1, Processing alpha-1, 2-mannosidase IC, Alpha-1, 2-mannosidase IC, MAN1C1, MAN1A3, MAN1C|
|Target/Specificity||This MAN1C1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 89-120 amino acids from human MAN1C1.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAN1C1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta|
Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.
Tremblay L.O.,et al.J. Biol. Chem. 275:31655-31660(2000).
Gregory S.G.,et al.Nature 441:315-321(2006).