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SYNJ2BP Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SYNJ2BP Antibody (N-Term) AP22192a
    Anti-SYNJ2BP Antibody (N-Term) at 1:2000 dilution + PC-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 16 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P57105
Other Accession Q9D6K5, Q9WVJ4
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Additional info
Other Names Synaptojanin-2-binding protein, Mitochondrial outer membrane protein 25, SYNJ2BP, OMP25
Target/Specificity This SYNJ2BP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 22-66 amino acids from human SYNJ2BP.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYNJ2BP Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNJ2BP
Synonyms OMP25
Function Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.
Cellular Location Mitochondrion outer membrane. EMBL; AY534623; AAT01566.1; -; mRNA EMBL; AK002133; BAA92098.1; -; mRNA EMBL; CH471061; EAW81032.1; -; Genomic_DNA EMBL; BC007704; AAH07704.1; -; mRNA CCDS; CCDS9803.1; - RefSeq; NP_060843.2; NM_018373.2 UniGene; Hs.443661; - UniGene; Hs.704691; - PDB; 2ENO; NMR; -; A=1-107 PDB; 2JIK; X-ray; 1.35 A; A/B=6-100 PDB; 2JIN; X-ray; 1.50 A; A=4-99 PDBsum; 2ENO; - PDBsum; 2JIK; - PDBsum; 2JIN; - ProteinModelPortal; P57105; - SMR; P57105; - BioGrid; 120614; 45 IntAct; P57105; 22 STRING; 9606.ENSP00000256366; - TCDB; 8.A.24.1.5; the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family iPTMnet; P57105; - PhosphoSitePlus; P57105; - BioMuta; SYNJ2BP; - DMDM; 22261816; - EPD; P57105; - jPOST; P57105; - MaxQB; P57105; - PaxDb; P57105; - PeptideAtlas; P57105; - PRIDE; P57105; - ProteomicsDB; 57004; - TopDownProteomics; P57105; - Ensembl; ENST00000256366; ENSP00000256366; ENSG00000213463 GeneID; 55333; - KEGG; hsa:55333; - UCSC; uc001xmc.5; human CTD; 55333; - DisGeNET; 55333; - EuPathDB; HostDB:ENSG00000213463.4; - GeneCards; SYNJ2BP; - HGNC; HGNC:18955; SYNJ2BP HPA; HPA000866; - MIM; 609411; gene neXtProt; NX_P57105; - OpenTargets; ENSG00000213463; - PharmGKB; PA38768; - eggNOG; ENOG410ITA3; Eukaryota eggNOG; ENOG4111VAQ; LUCA GeneTree; ENSGT00830000128402; - HOGENOM; HOG000146436; - HOVERGEN; HBG061461; - InParanoid; P57105; - KO; K20057; - OrthoDB; 1502481at2759; - PhylomeDB; P57105; - TreeFam; TF318964; - EvolutionaryTrace; P57105; - GeneWiki; SYNJ2BP; - GenomeRNAi; 55333; - PRO; PR:P57105; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000213463; Expressed in 236 organ(s), highest expression level in renal medulla ExpressionAtlas; P57105; baseline and differential Genevisible; P57105; HS GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central GO; GO:0030054; C:cell junction; IBA:GO_Central GO; GO:0031307; C:integral component of mitochondrial outer membrane; IEA:Ensembl GO; GO:0005739; C:mitochondrion; IDA:UniProtKB GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central GO; GO:0043005; C:neuron projection; IBA:GO_Central GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central GO; GO:0035255; F:ionotropic glutamate receptor binding; IBA:GO_Central GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central GO; GO:0048312; P:intracellular distribution of mitochondria; IEA:Ensembl GO; GO:0016525; P:negative regulation of angiogenesis; IMP:UniProtKB GO; GO:0010596; P:negative regulation of endothelial cell migration; IMP:UniProtKB GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:UniProtKB GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:UniProtKB GO; GO:1903671; P:negative regulation of sprouting angiogenesis; IMP:UniProtKB GO; GO:0006605; P:protein targeting; IEA:Ensembl GO; GO:0043113; P:receptor clustering; IBA:GO_Central GO; GO:0097120; P:receptor localization to synapse; IBA:GO_Central GO; GO:0030100; P:regulation of endocytosis; IEA:Ensembl GO; GO:0008593; P:regulation of Notch signaling pathway; IMP:UniProtKB GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl InterPro; IPR001478; PDZ InterPro; IPR036034; PDZ_sf Pfam; PF00595; PDZ; 1 SMART; SM00228; PDZ; 1 SUPFAM; SSF50156; SSF50156; 1 PROSITE; PS50106; PDZ; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 145 Synaptojanin-2-binding protein /FTId=PRO_0000072383 TOPO_DOM 1 117 Cytoplasmic. TRANSMEM 118 138 Helical. TOPO_DOM 139 145 Mitochondrial intermembrane DOMAIN 13 100 PDZ. {ECO:0000255|PROSITE- ProRule:PRU00143} VARIANT 9 9 V -> I (in dbSNP:rs4356408) /FTId=VAR_051394 CONFLICT 68 68 V -> A (in Ref. 2; BAA92098) HELIX 6 8 {ECO:0000244|PDB:2JIK} STRAND 9 17 {ECO:0000244|PDB:2JIK} STRAND 20 22 {ECO:0000244|PDB:2ENO} STRAND 25 29 {ECO:0000244|PDB:2JIK} TURN 31 33 {ECO:0000244|PDB:2ENO} STRAND 35 38 {ECO:0000244|PDB:2ENO} STRAND 42 47 {ECO:0000244|PDB:2JIK} STRAND 49 51 {ECO:0000244|PDB:2ENO} HELIX 52 56 {ECO:0000244|PDB:2JIK} STRAND 64 68 {ECO:0000244|PDB:2JIK} HELIX 78 86 {ECO:0000244|PDB:2JIK} STRAND 90 100 {ECO:0000244|PDB:2JIK} SEQUENCE 145 AA; 15928 MW; A62A82AC06A64995 CRC64; MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL
Research Areas

REFERENCES

Yang Y.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Tickle J.,et al.Submitted (JUN-2007) to the PDB data bank.

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