|Application ||WB, E|
|Calculated MW||109998 Da|
|Other Names||Poly [ADP-ribose] polymerase 10, PARP-10, 220.127.116.11, ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, PARP10|
|Target/Specificity||This PARP10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 565-597 amino acids from the Central region of human PARP10.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PARP10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ADP-ribosyltransferase that mediates mono-ADP- ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737).|
|Cellular Location||Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325). A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325).|
|Tissue Location||Highly expressed in spleen and thymus (PubMed:15674325). Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes (PubMed:15674325). Low expression in heart, brain, placenta, lung, skeletal muscle, and colon (PubMed:15674325)|
Provided below are standard protocols that you may find useful for product applications.
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
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