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FERMT3 Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FERMT3 Antibody (N-Term) AP22172a
    Anti-FERMT3 Antibody (N-Term) at 1:2000 dilution + mouse spleen lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 76 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q86UX7
Other Accession Q8K1B8
Reactivity Mouse
Predicted Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 75953 Da
Additional info
Gene ID 83706
Other Names Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2, FERMT3, KIND3, MIG2B, URP2
Target/Specificity This FERMT3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids from human FERMT3.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFERMT3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FERMT3
Synonyms KIND3, MIG2B, URP2
Function Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).
Cellular Location Cell projection, podosome. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
Tissue Location Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
Research Areas

BACKGROUND

Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).

REFERENCES

Weinstein E.J.,et al.Biochim. Biophys. Acta 1637:207-216(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Boyd R.S.,et al.Leukemia 17:1605-1612(2003).
Wang L.,et al.Biochem. Biophys. Res. Commun. 368:899-906(2008).
Mory A.,et al.Blood 112:2591-2591(2008).

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