|Application ||WB, E|
|Calculated MW||75953 Da|
|Other Names||Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2, FERMT3, KIND3, MIG2B, URP2|
|Target/Specificity||This FERMT3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids from human FERMT3.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FERMT3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIND3, MIG2B, URP2|
|Function||Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).|
|Cellular Location||Cell projection, podosome. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.|
|Tissue Location||Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.|
Provided below are standard protocols that you may find useful for product applications.
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).
Weinstein E.J.,et al.Biochim. Biophys. Acta 1637:207-216(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Boyd R.S.,et al.Leukemia 17:1605-1612(2003).
Wang L.,et al.Biochem. Biophys. Res. Commun. 368:899-906(2008).
Mory A.,et al.Blood 112:2591-2591(2008).