|Application ||WB, E|
|Calculated MW||38735 Da|
|Other Names||Glucose-6-phosphatase 3, G-6-Pase 3, G6Pase 3, 220.127.116.11, Glucose-6-phosphatase beta, G6Pase-beta, Ubiquitous glucose-6-phosphatase catalytic subunit-related protein, G6PC3, UGRP|
|Target/Specificity||This G6PC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 215-246 amino acids from human G6PC3.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||G6PC3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed. Highly expressed in skeletal muscle, at intermediate levels in heart, brain, placenta, kidney, colon, thymus, spleen and pancreas. Also detected in testis, prostate, ovary, liver, lung, small intestine and peripheral blood lymphocytes.|
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Martin C.C.,et al.J. Mol. Endocrinol. 29:205-222(2002).
Guionie O.,et al.FEBS Lett. 551:159-164(2003).
Shieh J.-J.,et al.J. Biol. Chem. 278:47098-47103(2003).
Ghosh A.,et al.J. Biol. Chem. 279:12479-12483(2004).