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FAM125A Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FAM125A Antibody (Center) AP22166c
    All lanes : Anti-FAM125A Antibody (Center) at 1:2000 dilution Lane 1: U-2OS whole cell lysate Lane 2: U-251 MG whole cell lysate Lane 3: A431 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 29 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96EY5
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 28783 Da
Additional info
Gene ID 93343
Other Names Multivesicular body subunit 12A, CIN85/CD2AP family-binding protein, ESCRT-I complex subunit MVB12A, Protein FAM125A, MVB12A, CFBP, FAM125A
Target/Specificity This FAM125A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 152-186 amino acids from the Central region of human FAM125A.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFAM125A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MVB12A
Synonyms CFBP, FAM125A
Function Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor.
Cellular Location Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with F-actin. Some fraction may be nuclear
Tissue Location Ubiquitously expressed except in skeletal muscle.
Research Areas

BACKGROUND

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor.

REFERENCES

Konishi H.,et al.J. Biol. Chem. 281:28919-28931(2006).
Beausoleil S.A.,et al.Nat. Biotechnol. 24:1285-1292(2006).
Morita E.,et al.Cell Host Microbe 2:41-53(2007).
Morita E.,et al.EMBO J. 26:4215-4227(2007).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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