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DBN1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q16643 |
| Other Accession | Q9QXS6, Q07266 |
| Reactivity | Human, Mouse |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 71429 Da |
| Gene ID | 1627 |
|---|---|
| Other Names | Drebrin, Developmentally-regulated brain protein, DBN1, D0S117E |
| Target/Specificity | This DBN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 194-228 amino acids from the Central region of human DBN1. |
| Dilution | WB~~1:2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DBN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DBN1 |
|---|---|
| Synonyms | D0S117E |
| Function | Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. |
| Cellular Location | Cytoplasm. Cytoplasm, cell cortex. Cell junction. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) |
| Tissue Location | Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level). |
Research Areas
BACKGROUND
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.
REFERENCES
Toda M.,et al.Biochem. Biophys. Res. Commun. 196:468-472(1993).
Fisher L.W.,et al.Neurosci. Res. Commun. 14:35-42(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Schmutz J.,et al.Nature 431:268-274(2004).
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