|Application ||WB, E|
|Other Accession||Q9QXS6, Q07266|
|Calculated MW||71429 Da|
|Other Names||Drebrin, Developmentally-regulated brain protein, DBN1, D0S117E|
|Target/Specificity||This DBN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 194-228 amino acids from the Central region of human DBN1.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DBN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.|
|Cellular Location||Cytoplasm. Cytoplasm, cell cortex. Cell junction. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC)|
|Tissue Location||Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level).|
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.
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