Profilin-1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| FC, WB, E |
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Primary Accession | P07737 |
Other Accession | P02584, P62962, P62963 |
Reactivity | Human, Mouse, Rat |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit Ig |
Calculated MW | 15054 Da |
Gene ID | 5216 |
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Other Names | Profilin-1, Epididymis tissue protein Li 184a, Profilin I, PFN1 |
Target/Specificity | This Profilin-1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-140 amino acids from the human region of human Profilin-1. |
Dilution | FC~~1:25 WB~~1:2000 |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Profilin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PFN1 |
---|---|
Function | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. |
Cellular Location | Cytoplasm, cytoskeleton. |
Tissue Location | Expressed in epididymis (at protein level). |
BACKGROUND
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
REFERENCES
Kwiatkowski D.J.,et al.J. Biol. Chem. 263:5910-5915(1988).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.

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