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GAS6 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GAS6 Antibody (Center) AP22089c
    All lanes : Anti-GAS6 Antibody (Center) at 1:2000 dilution Lane 1: rat plasma lysate Lane 2: SH-SY5Y whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 80 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q14393
Reactivity Human, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 79677 Da
Additional info
Gene ID 2621
Other Names Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand, GAS6, AXLLG
Target/Specificity This GAS6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 242-275 amino acids from the Central region of human GAS6.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGAS6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAS6
Synonyms AXLLG
Function Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Cellular Location Secreted.
Tissue Location Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen
Research Areas

BACKGROUND

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

REFERENCES

Manfioletti G.,et al.Mol. Cell. Biol. 13:4976-4985(1993).
Munoz X.,et al.Hum. Mutat. 23:506-512(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Maree A.O.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.

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