|Application ||WB, E|
|Calculated MW||91132 Da|
|Other Names||Nuclear GTPase SLIP-GC, 3.6.1.-, Speckled-like pattern in the germinal center, NUGGC, C8orf80|
|Target/Specificity||This C8orf80 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 27-59 amino acids from human C8orf80.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C8orf80 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).|
|Cellular Location||Nucleus speckle|
|Tissue Location||Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell|
Provided below are standard protocols that you may find useful for product applications.
Plays a role as replication-related GTPase protein in germinal center B-cell.
Nusbaum C.,et al.Nature 439:331-335(2006).
Yamada S.,et al.Oncogene 23:5901-5911(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Richter K.,et al.J. Biol. Chem. 284:30652-30661(2009).