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>   首页   >   产品   >   一抗   >   细胞生物学   >   FEM1B Antibody (C-Term)   

FEM1B Antibody (C-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FEM1B Antibody (C-Term) AP22084b
    All lanes : Anti-FEM1B Antibody (C-Term) at 1:2000 dilution Lane 1: 293T/17 whole cell lysate Lane 2: mouse testis lysate Lane 3: MCF-7 whole cell lysate Lane 4: rat testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 70 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9UK73
Other Accession Q9Z2G0, P0C6P7
Reactivity Human, Mouse, Rat
Predicted Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 70264 Da
Additional info
Gene ID 10116
Other Names Protein fem-1 homolog B, FEM1b, FEM1-beta, Fem-1-like death receptor-binding protein alpha, Fem-1-like in apoptotic pathway protein alpha, F1A-alpha, FEM1B, F1AA, KIAA0396
Target/Specificity This FEM1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 547-579 amino acids from human FEM1B.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFEM1B Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FEM1B
Synonyms F1AA, KIAA0396
Function Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Cellular Location Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin
Tissue Location Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
Research Areas

BACKGROUND

Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

REFERENCES

Chan S.-L.,et al.J. Biol. Chem. 274:32461-32468(1999).
Ventura-Holman T.,et al.Biochem. Biophys. Res. Commun. 267:317-320(2000).
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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