癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KLB Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86Z14 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 119808 Da |
| Gene ID | 152831 |
|---|---|
| Other Names | Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB |
| Target/Specificity | This KLB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from human KLB. |
| Dilution | WB~~1:2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLB Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLB |
|---|---|
| Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). |
| Cellular Location | Cell membrane; Single-pass type III membrane protein |
Research Areas
BACKGROUND
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
REFERENCES
Hayashi A.,et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Wu X.,et al.J. Biol. Chem. 283:33304-33309(2008).
Micanovic R.,et al.J. Cell. Physiol. 219:227-234(2009).
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