KLB Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application ![]()
| WB, E |
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Primary Accession | Q86Z14 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit Ig |
Calculated MW | 119808 Da |
Gene ID | 152831 |
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Other Names | Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB |
Target/Specificity | This KLB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from human KLB. |
Dilution | WB~~1:2000 |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KLB Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLB |
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Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). |
Cellular Location | Cell membrane; Single-pass type III membrane protein |
Research Areas
BACKGROUND
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
REFERENCES
Hayashi A.,et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Wu X.,et al.J. Biol. Chem. 283:33304-33309(2008).
Micanovic R.,et al.J. Cell. Physiol. 219:227-234(2009).

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