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>   首页   >   产品   >   一抗   >   代谢   >   KLB Antibody (N-Term)   

KLB Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - KLB Antibody (N-Term) AP22050a
    All lanes : Anti-KLB Antibody (N-Term) at 1:2000 dilution Lane 1: A549 whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 120 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q86Z14
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 119808 Da
Additional info
Gene ID 152831
Other Names Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB
Target/Specificity This KLB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from human KLB.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLB Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLB
Function Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Cellular Location Cell membrane; Single-pass type III membrane protein
Research Areas

BACKGROUND

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).

REFERENCES

Hayashi A.,et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Wu X.,et al.J. Biol. Chem. 283:33304-33309(2008).
Micanovic R.,et al.J. Cell. Physiol. 219:227-234(2009).

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