|Application ||WB, E|
|Other Accession||P14099, Q922S4, Q01062|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||105717 Da|
|Other Names||cGMP-dependent 3', 5'-cyclic phosphodiesterase, 220.127.116.11, Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE, PDE2A|
|Target/Specificity||This PDE2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 787-821 amino acids from human PDE2A.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE2A Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.|
|Cellular Location||Isoform PDE2A3: Cell membrane; Lipid-anchor Isoform PDE2A1: Cytoplasm|
|Tissue Location||Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas|
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Rosman G.J.,et al.Gene 191:89-95(1997).
Bugaj-Gaweda B.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Russwurm C.,et al.J. Biol. Chem. 284:25782-25790(2009).