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AKR7A3 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - AKR7A3 Antibody (Center) AP21988c
    All lanes : Anti-AKR7A3 Antibody (Center) at 1:2000 dilution Lane 1: human liver lysate Lane 2: SK-BR-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 37 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O95154
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 37206 Da
Additional info
Gene ID 22977
Other Names Aflatoxin B1 aldehyde reductase member 3, 1.-.-.-, AFB1 aldehyde reductase 2, AFB1-AR 2, AKR7A3, AFAR2
Target/Specificity This AKR7A3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 187-217 amino acids from the Central region of human AKR7A3.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAKR7A3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR7A3
Synonyms AFAR2
Function Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Cellular Location Cytoplasm.
Tissue Location Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
Research Areas

BACKGROUND

Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

REFERENCES

Knight L.P.,et al.Carcinogenesis 20:1215-1223(1999).
Praml C.,et al.Oncogene 22:4765-4773(2003).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bodreddigari S.,et al.Chem. Res. Toxicol. 21:1134-1142(2008).

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