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TTN Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 14 - TTN Antibody (N-term) AP21985a
    AP21985a staining TTN in human skeletal muscle sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, E
Primary Accession Q8WZ42
Other Accession A2ASS6
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 3816030 Da
Additional info
Gene ID 7273
Other Names Titin, 2.7.11.1, Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14, TTN
Target/Specificity This TTN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 7169-7203 amino acids from the N-terminal region of human TTN.
Dilution IHC-P~~1:25
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTTN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTN
Function Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
Cellular Location Cytoplasm. Nucleus
Tissue Location Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle Isoform 6 is expressed in skeletal muscle (at protein level)
Research Areas

BACKGROUND

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

REFERENCES

Labeit S.,et al.Science 270:293-296(1995).
Freiburg A.,et al.Circ. Res. 86:1114-1121(2000).
Bang M.-L.,et al.Circ. Res. 89:1065-1072(2001).
Hillier L.W.,et al.Nature 434:724-731(2005).
Gautel M.,et al.J. Cell Sci. 109:2747-2754(1996).

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