癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PHF6 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IF, WB, E |
|---|---|
| Primary Accession | Q8IWS0 |
| Other Accession | Q08DR0, Q5R5Z2 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 41290 Da |
| Gene ID | 84295 |
|---|---|
| Other Names | PHD finger protein 6, PHD-like zinc finger protein, PHF6, CENP-31, KIAA1823 |
| Target/Specificity | This PHF6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 315-349 amino acids from human PHF6. |
| Dilution | IF~~1:25 WB~~1:2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PHF6 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PHF6 |
|---|---|
| Synonyms | CENP-31, KIAA1823 |
| Function | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. |
| Cellular Location | Nucleus. Nucleus, nucleolus. Chromosome, centromere, kinetochore Note=Nuclear, it particularly localizes to the nucleolus |
| Tissue Location | Ubiquitously expressed. |
BACKGROUND
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
REFERENCES
Lower K.M.,et al.Nat. Genet. 32:661-665(2002).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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