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>   首页   >   产品   >   一抗   >   癌症   >   ADCY5 Antibody (Center)   

ADCY5 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ADCY5 Antibody (Center) AP21676c
    All lanes : Anti-ADCY5 Antibody (Center) at 1:1000-1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: SH-SY5Y whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 139 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O95622
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 138908 Da
Additional info
Gene ID 111
Other Names Adenylate cyclase type 5, ATP pyrophosphate-lyase 5, Adenylate cyclase type V, Adenylyl cyclase 5, ADCY5
Target/Specificity This ADCY5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 604-639 amino acids from the Central region of human ADCY5.
Dilution WB~~1:1000-1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADCY5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADCY5
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250|UniProtKB:P84309}
Tissue Location Detected in pancreas islets (at protein level). Detected in pancreas islets
Research Areas

BACKGROUND

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

REFERENCES

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ludwig M.G.,et al.J. Recept. Signal Transduct. 22:79-110(2002).
Raimundo S.,et al.Clin. Chim. Acta 285:155-161(1999).
Ding Q.,et al.Mol. Pharmacol. 66:921-928(2004).

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