|Application ||WB, E|
|Calculated MW||59491 Da|
|Other Names||Insulinoma-associated protein 2, Zinc finger protein IA-6, INSM2, IA6|
|Target/Specificity||This INSM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 192-227 amino acids from the Central region of human INSM2.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INSM2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level)|
May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
Cai T.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
Halford S.,et al.Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
Ohira M.,et al.Cancer Lett. 197:63-68(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).