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>   首页   >   产品   >   一抗   >   免疫学   >   CLEC16A Antibody (C-term)   

CLEC16A Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CLEC16A Antibody (C-term) AP21278b
    All lanes : Anti-CLEC16A Antibody (C-term) at 1:1000 dilution Lane 1: T47D whole cell lysates Lane 2: mouse heart lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 118 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q2KHT3
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 117715 Da
Additional info
Gene ID 23274
Other Names Protein CLEC16A, C-type lectin domain family 16 member A {ECO:0000312|HGNC:HGNC:29013}, CLEC16A (HGNC:29013), KIAA0350
Target/Specificity This CLEC16A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 773-805 amino acids from the C-terminal region of human CLEC16A.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLEC16A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLEC16A (HGNC:29013)
Synonyms KIAA0350
Function Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Cellular Location Endosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein Lysosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein. Note=Associates with the endolysosome membrane {ECO:0000250|UniProtKB:Q80U30}
Tissue Location Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells
Research Areas

BACKGROUND

Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.

REFERENCES

Nagase T.,et al.DNA Res. 4:141-150(1997).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hakonarson H.,et al.Nature 448:591-594(2007).
Soleimanpour S.A.,et al.Cell 157:1577-1590(2014).

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