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DCC Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DCC Antibody (C-term) AP21272b
    All lanes : Anti-DCC Antibody (C-term) at 1:1000 dilution Lane 1: U-87 MG whole cell lysates Lane 2: human brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 158 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P43146
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 158457 Da
Additional info
Gene ID 1630
Other Names Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Target/Specificity This DCC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1048-1082 amino acids from the C-terminal region of human DCC.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDCC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCC
Synonyms IGDCC1
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells
Research Areas

BACKGROUND

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

REFERENCES

Hedrick L.,et al.Genes Dev. 8:1174-1183(1994).
Nusbaum C.,et al.Nature 437:551-555(2005).
Fearon E.R.,et al.Science 247:49-56(1990).
Nigro J.M.,et al.Cell 64:607-613(1991).
Cho K.R.,et al.Genomics 19:525-531(1994).

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