|Application ||WB, E|
|Calculated MW||60786 Da|
|Other Names||Guanine nucleotide-binding protein-like 3, Nucleolar GTP-binding protein 3, Nucleostemin, Gnl3, Ns|
|Target/Specificity||This Mouse Gnl3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 420-454 amino acids from the C-terminal region of Mouse Gnl3.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||(Mouse) Gnl3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus|
|Tissue Location||Expressed in the adult bone marrow population that is enriched in hematopoietic stem cells|
May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.
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Carninci P.,et al.Science 309:1559-1563(2005).
Trost M.,et al.Immunity 30:143-154(2009).
Meng L.,et al.Oncogene 30:1716-1726(2011).